Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Semagacestat is an inhibitor of the ╬│-secretase enzyme. ╬│-Secretase enzyme is pivotal in the generation of b-amyloid (Ab), a neurotoxic endogenous peptide believed to be involved in the pathogenesis of Alzheimer's disease (AD).
Portelius, E. et al.: Alzheim. Res. Ther., 22. No pp. given (2010); Imbimbo, B.P. et al.: Curr. Opin. Invest. Drugs, 10, 721 (2009); Panza, F. et al.: Curr. Med. Chem., 18, 5430 (2011);
400-821-0725
沪ICP备17019645号
