, N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl Ester ,

：纯度： CAS：

英文名称：N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl Ester

品牌：TRC

规格	目录价格	会员价格	数量
5mg	￥ ĨǐŕţŊǐǐ	一般3-5周，以TRC实际库存为准	￥ ĨǐŕţŊǐǐ	- +
10mg	￥ ĿĨŕǐŊǐǐ	一般3-5周，以TRC实际库存为准	￥ ĿĨŕǐŊǐǐ	- +
25mg	￥ ţȕţŕŕŊǐǐ	一般3-5周，以TRC实际库存为准	￥ ţȕţŕŕŊǐǐ	- +

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基本信息

英文名称

N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl Ester

分子式

C15 H14 O2

Smiles Code

纯度

Standards; Chiral Molecules; Amino Acids; Pharmaceutical/API Drug Impurities/Metabolites;

N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl Ester is an intermediate in the synthesis of Sofosbuvir (R)-Phosphate (S675615), which is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-a-fluoro-b-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.

Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010)

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质量 (g) = 浓度 (mol/L) × 体积 (L) × (g/mol)

质量			浓度			体积			*
		=			×			×

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