Building Blocks; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites; Phenethylamines/Amphetamines;
(R)-Laudanosine is an isomer of (S)-Laudanosine (L178525), a metabolite of the neuromuscular-blocking drugs Atracurium (A794500) and Cisatracurium (C496700) with potentially toxic systemic effects. It crosses the blood-brain barrier and may cause excitement and seizure activity.
Canfell, P., et al.: Drug Metab. Dispos., 14, 703 (1986); Anselmi, E., et al.: J. Pharm. Pharmacol., 44, 337 (1992); Bohrer, H., et al.: Pharmacol. Toxicol., 73, 137 (1993)
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