Smiles Code
CCN1C(=O)C(=CC2=CNC(=Nc3ccc(cc3)N4CCN(C)CC4)N=C12)c5ccc(cc5Cl)c6cncs6
Standards; Enzyme Activators and Inhibitors;
p21-activated kinases (Paks) are serine/threonine protein kinases involved in cellular signaling pathways. PAK1 is an effector of Rho GTPase. PAKs are oncogenic kinases, which have been implicated as potential therapeutic targets. FRAX 597 is a PAK1 inhibitor that can reduce pancreatic cancer growth when used with Gemcitabine (G305000), an antineoplastic agent.
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