Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites;
3-Deoxy-3S-chloroabiraterone is an impurtiy of Abiraterone (A108490), which is a steroidal cytochrome P 450 17a-hydroxylase-17,20-lyase inhibitor (CYP17) and is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer.
Denis, L., et al.: Cancer, 72, 3888 (1993); Potter, G.A., et al.: J. Med. Chem., 38, 2463 (1995); Denmeade, S., et al.: Nat. Rev., 2, 389 (2002); Scher, H., et al.: J. Clin. Oncol., 23, 8253 (2005)
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