英文名称
N-Cyanomethyl Cyclopamine
Standards; Chiral Molecules; Steroids; Pharmaceutical/API Drug Impurities/Metabolites;
N-Cyanomethyl Cyclopamine is an intermediate in the synthesis of 3-Keto-N-aminoethyl-N’-aminocaproyldihydrocinnamoyl Cyclopamine(K171000). Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects of oncogenic mutations in Smoothened and Patched.1 The KAAD-Cyclopamine has shown 10-20 fold higher potency than cyclopamine in inhibition of ß-Galactosidase expression in p2Ptch-1- cells, with similar or lower toxicity.
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